The purpose of the Care of the Pediatric Patient with a Brain Tumor clinical practice guideline (CPG) is to provide an up-to-date and thorough review and assessment of the literature; nursing care recommendations based on the evidence in the literature; and, in the absence of published scientific evidence, recommendations based on expert opinion. The intended audience is bedside nurses caring for pediatric patients with brain tumors. This comprehensive, yet concise, review will serve as a reference for the care of children with brain tumors, from acute diagnosis to long-term survivorship.