Epilepsy is a chronic condition which has devastating physiological, psychological, and social consequences. Anti-epileptic medications are the first line treatment, and for many patients, the mainstay of treatment. About 35% of patients with focal epilepsy are resistant to medications. Respective surgery, including temporal lobectomy and extra-temporal epilepsy surgery, is a potentially curative procedure for patients with drug-resistant epilepsy. In order to be considered for these procedures, patients must have one clearly identified seizure focus which is in an area safe to remove. For patients who have multifocal seizures, generalized seizures, or one seizure focus located in eloquent cortex, implantable devices are now available as a non-medication treatment option. Neuroscience nurses are often involved in the care of epilepsy patients and are important members of the treatment team; therefore, they can play a vital role in patient education regarding treatment options.